- Title
- Clinical characteristics of patients with asthma COPD overlap (ACO) in australian primary care
- Creator
- Izbicki, Gabriel; Teo, Valerie; Phillips, Kirsten; Wilson, Sally; George, Johnson; Abramson, Michael J.; Liang, Jenifer; Russell, Grant M.; Holland, Anne E.; Zwar, Nicholas A.; Bonevski, Billie; Mahal, Ajay; Eustace, Paula; Paul, Eldho
- Relation
- NHMRC Career Devopment Fellowship.GNT1063206
- Relation
- International Journal of COPD Vol. 14, p. 2745-2752
- Publisher Link
- http://dx.doi.org/10.2147/COPD.S220346
- Publisher
- Dove Medical Press Ltd. (DovePress)
- Resource Type
- journal article
- Date
- 2019
- Description
- Purpose: Many older adults with a history of smoking and asthma develop clinical features of both asthma and COPD, an entity sometimes called asthma-COPD overlap (ACO). Patients with ACO may be at higher risk of poor health outcomes than those with asthma or COPD alone. However, understanding of ACO is limited in the primary care setting and more information is needed to better inform patient management. We aimed to compare the characteristics of patients with ACO or COPD in Australian general practices. Patients and methods: Data were from the RADICALS (Review of Airway Dysfunction and Interdisciplinary Community-based care of Adult Long-term Smokers) trial, an intervention study of an interdisciplinary community-based model of care. Baseline demographic and clinical characteristics, pre-and post bronchodilator spirometry, dyspnoea and St. George's Respiratory Questionnaire scores were compared between 60 ACO patients and 212 with COPD alone. Results: Pre-bronchodilator Forced Expiratory Volume in 1 second (mean±SD 58.4±14.3 vs 67.5±20.1% predicted) and Forced Vital Capacity (mean 82.1±16.9 v 91.9±17.2% predicted) were significantly lower in the ACO group (p<0.001), but no difference was found in post-bronchodilator spirometry. Demographic and clinical characteristics, dyspnoea, quality of life, comorbidities and treatment prescribed did not differ significantly between groups. Conclusion: This is the first study describing the clinical characteristics of ACO patients in Australian general practices. Our finding of lower pre-bronchodilator lung function in the ACO group compared to those with COPD reinforces the importance of spirometry in primary care to inform management.
- Subject
- asthma; chronic obstructive pulmonary disease; primary care; spirometry; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1457383
- Identifier
- uon:45336
- Identifier
- ISSN:1176-9106
- Rights
- © 2019 Izbicki et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
- Language
- eng
- Full Text
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